Detection and imaging of Hg(II) in vivo using glutathione-functionalized gold nanoparticles

• Gufeng Li,
• Shaoqing Li,
• Rui Wang,
• Min Yang,
• Lizhu Zhang,
• Yanli Zhang,
• Wenrong Yang and
• Hongbin Wang

Beilstein J. Nanotechnol. 2022, 13, 549–559, doi:10.3762/bjnano.13.46

• the fluorescent “ON” form. Keywords: cell imaging; fluorescence probes; glutathione; gold nanoparticles; mercury ions; rhodamine 6G derivatives; Introduction Metal nanoparticles have been widely used in the development and construction of sensor systems and drug carriers due to their excellent

• . Conclusion In this work, we conjugated GNPs with rhodamine 6G derivatives by surface functionalization of gold nanoparticles with glutathione. The conjugates can be used to generate a fluorescence signal in the presence of Hg2+. The fluorescence signal of GNPs-GSH-Rh6G2 in HEPES buffer solution shows a